Results: In comparison to matched healthy controls, the PD patients revealed decreased relative proton density in contralateral prefrontal subcortical area, upper and lower pons, in ipsilateral globus pallidus, and bilaterally in splenium corporis callosi, caudate nucleus, putamen, thalamus, and mesencephalon. Brain relative proton density, T1, T2, and T2′ relaxation times were measured in 14 regions of interest (ROIs) in each hemisphere and compared between patients and controls to estimate PD related alterations. Methods: Cerebral MRI at 3T was performed on 20 PD patients in early stages and 20 age and sex matched healthy controls.
In this study, microstructural changes in relevant brain regions of early PD patients were investigated by using quantitative MRI methods. Advanced imaging approaches are necessary to discriminate early PD patients from healthy controls. In early stages of PD, patients typically display normal brain magnet resonance imaging (MRI) in routine screening. Objective: Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly.
Höglinger 1, Heinrich Lanfermann 2 and Xiao-Qi Ding 2 Handan Elaman 2†, Nima Mahmoudi 2, Patrick Nösel 2, Mareike Ahlswede 2, Florian Wegner 1, Günter U.
